He hosted many shows at PSTV, including Late Night with Dave Annable, Cardinal Sports, and The Roommate Game.
They lasted a little over a year before Emily left the show and Dave's now-wife, Odette Yustman, was cast as his new love interest.
666 Park Avenue returned to ABC in June 2013 to burn off its remaining episodes.
In 2014, Annable starred on the Fox series Red Band Society, where he played the role of pediatric oncologist and surgeon Dr. Annable had a relationship with his Brothers & Sisters co-star Emily Van Camp beginning in 2007, who later became his love interest on the series.
His best known roles include Justin Walker on the ABC television drama Brothers & Sisters (2006–11), Henry Martin on the ABC supernatural drama 666 Park Avenue (2012–13), Dr.
Adam Mc Andrew on the Fox medical drama Red Band Society (2014–15) and Pierce Harrison on the NBC medical drama Heartbeat (2016). He grew up in Walden, a village in New York, where he played baseball, rugby and hockey.